Nasal Polyps Reasearchs and Treatment

The pathogenesis of  Nasal Polyps involves production of secretions in the paranasal sinuses in response to viral infection and secondary bacterial infection, followed by accumulation of these secretions in the sinuses due to impaired drainage and development of persis¬tent inflammation. Patients with Nasal Polyps complain of symptoms such as purulent nasal discharge, nasal obstruction, headache, cheek pain, and toothache. Criteria for determining the severity were defined, with two factors being assessed to determine the severity of Nasal Polyps. The first factors are a peripheral blood eosinophil percentage of more than 5% and ethmoid sinus-predominant involvement on CT scans. The second factor is the presence of complications (current asthma or a history of asthma, aspirin intolerance, and/or NSAID allergy). Eventually, Nasal Polyps was classified into the following three categories:  mild Nasal Polyps, moderate Nasal Polyps, and severe Nasal Polyps. After surgery treatment...

Epithelial proliferation and differentiation have been implicated in the pathogenesis of nasal polyposis, but the underlying mechanisms remain unknown. Though polyps are reported to contain inflammatory cells which could play important roles, development of nasal polyposis is likely to involve several other factors. The role of epithelial cells is still uncertain. We hypothesized that delayed cellular apoptosis has a major role in the pathogenesis of nasal polyps. The study group comprised polyps removed endoscopically from 20 consecutive patients. Ethmoid mucosa from 4 patients who underwent orbital decompression for Graves' opthalmopathy was used as controls. Human subjects committee approved the study. Apoptosis in fixed polyp or tissue sections was assessed by labeling free 3'-hydroxyl groups of DNA using a Trevigen terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) peroxidase assay kit and counterstaining with hematoxylin. TU...